Forecasters have upgraded weekend weather warnings to amber for snow and ice across the area.
The first yellow warning is in place from 12pm tomorrow (Saturday, January 4) until 11.59pm on Sunday. Meanwhile, an amber warning has also been issued from 6pm tomorrow until 12pm on Sunday.
The UK Health Security Agency (UKHSA) has also issued an amber cold health alert which is in place until 12pm next Wednesday (January 8). People have been warned of significant disruption across health and social care services.
The Met Office warning states: "Snow will become persistent and locally heavy as it pushes south to north across the warning area. As well as snow, a period of freezing rain is also likely bringing some hazardous travel conditions, before milder air follows across all areas by Sunday morning.
“Whilst there is some uncertainty in details, 3-7 cm of snow is likely for much of the warning area, with locally 15-30 cm for the higher ground of Wales and the southern Pennines. Freezing rain could lead to ice accretion in places, especially parts of Wales, before the milder air leads to a rapid thaw of snow and ice in the south of the warning area through Sunday.”
The forecaster continued: "Outbreaks of rain spreading progressively northeastwards later on Saturday and overnight into Sunday will likely be preceded by a spell of snow on its northern flank. Whilst there is some uncertainty, any snow in southern and eastern parts of England, especially at low levels, will probably be rather transient before turning back to rain. However, some significant accumulations of snow are possible across parts of Wales, the Midlands and northern England in particular, at least for a time, where 5 cm or more could accumulate fairly widely, with perhaps as much as 20-30 cm over high ground of mid and north Wales and potentially 30-40 cm over parts of the Pennines. This, accompanied by strengthening winds, may lead to drifting of lying snow.
"In addition, as milder air moves northwards, snow may turn to a spell of freezing rain for a time, again more especially across parts of Wales, the Midlands and northern England, adding to the risk of ice and leading to some treacherous conditions in places. A fairly rapid thaw of lying snow is possible later on Sunday, although exactly how far north the rapid thaw will reach remains uncertain at this stage.”
The Met Office says there could be power cuts, travel disruption and some rural communities could be cut off.